Home Alone 2: Lost in New York was filmed on location in New York City and surrounding areas. The production team made use of various iconic locations, including the Plaza Hotel, Central Park, and the New York City streets. The film's budget was estimated to be around $28 million, which is approximately $50 million in today's dollars.

The movie picks up where the first film left off, with 8-year-old Kevin McCallister (Macaulay Culkin) accidentally separated from his family during the holidays. This time, Kevin finds himself in New York City, where he checks into the Plaza Hotel using his father's credit card. While enjoying his newfound freedom, Kevin soon realizes that he must defend his hotel against a pair of bumbling burglars, Harry and Marv (Joe Pesci and Daniel Stern).

As Kevin navigates the challenges of being alone in the big city, he also befriends a kind-hearted concierge, Brenda (Brenda Fricker), and a panhandler, Ethel (Ellen Barkin). Meanwhile, Kevin's family frantically searches for him, leading to a series of hilarious misadventures.

Home Alone 2: Lost in New York has had a lasting impact on popular culture. The movie's portrayal of a young boy outsmarting bumbling burglars has become an iconic trope in holiday entertainment. The film's success also helped to establish Macaulay Culkin as a household name, cementing his status as a talented young actor.